Detail information of PDX- BLC00423

  • Growth Properties

图片1.png

Fig 1. Growth Properties

  • Pathology Diagnosis

Tumor size: Bladder size 12×10×4 cm. Incision of the bladder reveals a growing mass in the ring cavity, 7×5×1.6 cm in size.

Histological type: Invasive urothelial carcinoma (high grade).

Histological grading: High grade.

IHC: CK20 (minor+), CK7(+), P63 (+), Ki-67 (approximately 50%+), P53 (partial+).

  • Gene mutation results in WES sequencing

Table 1. Gene mutation results (Partial)

Gene

Hgvs

Priority

ATM

p.R468K; p.R476K; p.R521K

H

RET

p.G691S; p.G437S

L

FLT3

p.D7G; p.T227M

L

FGFR3

p.S249C

H

EZH2

p.D185H; p.D146H; p.D176H

L