Live Knockout Mice & Conditional Knockout Mice
GemPharmatech’s ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields including oncology, autoimmunity, metabolism, and neurodegeneration. Using CRISPR-Cas9 technology, we have also created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing nearly unlimited genetic combinations to fit your research objectives.
We offer live mice for featured strains to save the time for breeding and resuscitation which may greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date, first come, first serve.
Benefits：
Live mice in stock and ready to ship in as soon as two weeks
Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.
Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.
In-stock List (valid through April 10th, 2023)
KO & cKO Mice
Strain ID | Targeted Gene | Strain Type | Background | Genotype | Application |
| Sting1 | Cas9-KO | C57BL/6JGpt | Homozygous | Viral Infections, innate Immunity, autoimmunity, Cellular Stress and autophagy | |
| Nlrp3 | Cas9-KO | C57BL/6JGpt | Homozygous | Innate immunity, inflammatory response | |
| Ifnar1 | Cas9-KO | C57BL/6JGpt | Homozygous | Viral infection, inflammatory response, oncology-immunity | |
| Mettl3 | Cas9-cKO | C57BL/6JGpt | Heterozygous | M6A modification, cancers, etc. | |
| Zbp1 | Cas9-KO | C57BL/6JGpt | Heterozygous | Inflammatory response, necroptosis | |
| Nfe2l2 | Cas9-KO | C57BL/6JGpt | Heterozygous | Oxidative stress, inflammatory reaction, reproduction, etc. | |
| T005545 | Tnf | Cas9-KO | C57BL/6JGpt | Heterozygous | Developmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,Muscle ,respiratory system,adipose tissue,Cell Proliferation,Cell death,DNA transcription,reproductive system,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,cellular,craniofacial ,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,Cell localization,Lipid Metabolism,Cytoplasmic vesicle,endosome,Organelles membrane,DNA binding protein,Physiological system,Metabolic research,Cell biology,Molecular biology |
| T007997 | Nf1 | Cas9-CKO | C57BL/6JGpt | Homozygous | Metabolic research,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell |
| T011566 | Shank3 | Cas9-KO | C57BL/6JGpt | Homozygous | Synapses, autism |
| T017245 | Acss2 | Cas9-KO | C57BL/6JGpt | Heterozygous | Glucose metabolism,liver/biliary system,homeostasis/metabolism,Lipid Metabolism,cell nucleus,ligase,Metabolic research,digestive/alimentary system,Cell biology,Molecular biology,Physiological system |
| T018441 | Acly | Cas9-CKO | C57BL/6JGpt | Heterozygous | Glucose metabolism,Mitochondrial research,mortality/aging,Lipid Metabolism,cell nucleus,Organelles membrane,transferase,Metabolic research,Cell biology,Developmental Biology,Molecular biology |
| T052147 | Yap1 | Cas9-CKO | C57BL/6JGpt | Heterozygous | Hippo signaling pathway, development, growth, repair and endogenous homeostasis, cancer, etc. |
| T007891 | Mfn2 | Cas9-CKO | C57BL/6JGpt | Heterozygous | Metabolic research,homeostasis/metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous |
| T011513 | Padi4-KO | Cas9-KO | C57BL/6JGpt | Heterozygous | Immune system,Protein metabolism,cellular,growth/size/body,hematopoietic system,mortality/aging,cell nucleus,hydrolytic |
| T016449 | Acss2 | Cas9-CKO | C57BL/6JGpt | Heterozygous | Metabolic research,Glucose metabolism,homeostasis/metabolism,Lipid Metabolism,Physiological system,digestive/alimentary system,liver/biliary system,Cell biology,cell nucleus,Molecular biology,ligase |
| T019786 | Sik2 | Cas9-CKO | C57BL/6JGpt | Heterozygous | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,immune system,nervous system,behavior/neurological,Physiological system,integument,pigmentation,cardiovascular system,Muscle ,Cell biology,cellular,cell nucleus,Molecular biology,Signal Transduction,transferase |
| T051714 | Tlr4 | Cas9-KO | C57BL/6JGpt | Heterozygous | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,pigmentation,cardiovascular system,skeleton,Muscle ,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Cytoplasmic vesicle,endosome,Golgi apparatus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,hydrolytic enzyme,Lipid binding protein |
| T008889 | Fabp4 | Cas9-CKO | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,Physiological system,renal/urinary system |
| T013731 | Abcb11 | Cas9-KO | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,Physiological system,renal/urinary system |
| T052437 | Il33 | Cas9-KO | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,Physiological system,renal/urinary system |
| T003346 | Trem2 | Cas9-KO | C57BL/6JGpt | Heterozygous | Metabolic research,Protein metabolism,Glucose metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,immune system,nervous system,Physiological system,cardiovascular system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Organelles membrane,Molecular biology,Signal Transduction,Lipid binding protein,Disease and Drug Evaluation Model,Neurodegenerative diseases,Huntington's disease |
| T016185 | Mthfd2 | Cas9-CKO | C57BL/6JGpt | Heterozygous | Developmental Biology,embryo,growth/size/body,mortality/aging,nervous system,vision/eye,Physiological system,integument,cardiovascular system,skeleton,craniofacial ,digestive/alimentary system,liver/biliary system,Cell biology,Mitochondrial research,Molecular biology,hydrolytic enzyme,oxidordeuctase |
| T052860 | Fap | Cas9-KO | C57BL/6JGpt | Heterozygous | Metabolic research,Protein metabolism,Developmental Biology,immune system,nervous system,vision/eye,Physiological system,skeleton,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Organelles membrane,Molecular biology,hydrolytic enzyme |
Cre Mice
Strain ID | Targeted Gene | Strain Type | Background | Genotype | Application |
| Adipoq-P2A-iCre | Cas9-KI | C57BL/6JGpt | Homozygous | Theoretically labeled cell type: White adipose tissue, brown adipose tissue | |
| H11-Vil1-iCre-ployA | Cas9-KI(H11) | C57BL/6JGpt | Homozygous | Theoretically labeled cell type: Gut epithelial cells | |
| Rosa26-SA-CreERT2 | Cas9-KI(Rosa26) | C57BL/6JGpt | Homozygous | Expression system/tissue: Whole body (low activity in brain and skeletal muscle) | |
| Cd4-iCre | Cas9-KI(H11) | C57BL/6JGpt | Homozygous | Theoretically labeled cell type: Helper T cells (CD4+ T cells) | |
| T010829 | Tg(Prox1-CreERT2) | TG | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,immune system |
| T036859 | Ckmm-iCre-PolyA | TG | C57BL/6JGpt | Heterozygous | Cre/Dre,Tool Mice,adipose tissue,Metabolic research |
| T052789 | Lyz2-CreERT2 | Cas9-KI | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,immune system |
| H11-Stra8-iCre | Cas9-KI(H11) | C57BL/6JGpt | Homozygous | Theoretically labeled cell type: Seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells | |
| Lyve1-IRES-iCre | Cas9-KI | C57BL/6JGpt | Heterozygous | Expressed system/tissue: immune system; Theoretically labeled cell type: lymphatic vessel endothelial cells; no cellular level validation performed. | |
| H11-Cdh5-iCre | Cas9-KI | C57BL/6JGpt | Homozygous | Theoretically labeled cell type: vascular endothelial cells | |
| Calb1-P2A-iCre | Cas9-KI | C57BL/6JGpt | Heterozygous | Expressed system/tissue: nervous system (see strain information for details). Theoretically labeled cell type: central neuron; no cellular level validation performed. | |
| Cx3cr1-iCre | Cas9-KI | C57BL/6JGpt | Homozygous | Expressed system/tissue: immune system (see strain information for details). Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; no cellular level validation performed. | |
| Rosa26-EIIA-iCre | Cas9-KI(Rosa26) | C57BL/6JGpt | Heterozygous | Expressed system/tissue: systemic (see strain information for details). Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); no cellular level validation performed. | |
| T004829 | H11-Vil1-CreERT2-ployA | Cas9-KI（H11) | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,Physiological system,digestive/alimentary system |
| T017784 | alb-creERT2 | Cas9-KI(H11) | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,Physiological system,digestive/alimentary system,liver/biliary system |
| T005635 | H11-MMTV-iCre | Cas9-KI(H11) | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre |
| T006205 | Lrat-P2A-iCre | Cas9-KI | C57BL/6JGpt | Homozygous | Theoretically labeled cell type: Hepatic stellate cells |
| T052797 | Fos-CreERT2 | Cas9-KI | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,nervous system |
| T007046 | Cdh16-CreERT2 | Cas9-KI | C57BL/6JGpt | Homozygous | Tool Mice,Cre/Dre,Physiological system,renal/urinary system |
| T014691 | Cdh5-CreERT2 | TG | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,Physiological system,cardiovascular system |
| T055135 | Cd4-IRES-iCre | Cas9-KI | C57BL/6JGpt | Heterozygous | Tool Mice,Cre/Dre,immune system |
| T050812 | Upk2-P2A-iCre | Cas9-KI | C57BL/6JGpt | heterozygous | Tool Mice,Cre/Dre,Physiological system,renal/urinary system |
| T052686 | Cdh5-P2A-CreERT2 | Cas9-KI | C57BL/6JGpt | heterozygous | Tool Mice,Cre/Dre,Physiological system,renal/urinary system |
| T057690 | Pi16-creERT2 | Cas9-KI | C57BL/6JGpt | heterozygous | Tool Mice,Cre/Dre,Physiological system,renal/urinary system |
| T052693 | Aldh1l1-CreERT2 | Cas9-KI | C57BL/6JGpt | Homozygous | Tool Mice,Cre/Dre,nervous system |
Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.