Live Knockout Mice & Conditional Knockout Mice

GemPharmatech’s ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields including oncology, autoimmunity, metabolism, and neurodegeneration. Using CRISPR-Cas9 technology, we have also created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing nearly unlimited genetic combinations to fit your research objectives.

We offer live mice for featured strains to save the time for breeding and resuscitation which may greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date, first come, first serve.

Benefits:

  • Live mice in stock and ready to ship in as soon as two weeks

  • Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.

  • Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.

In-stock List (valid through April 10th, 2023)

KO & cKO Mice

Strain ID

Targeted Gene

Strain Type

Background

Genotype

Application

T012747

Sting1Cas9-KOC57BL/6JGptHomozygousViral Infections, innate Immunity, autoimmunity, Cellular Stress and autophagy

T010873

Nlrp3Cas9-KOC57BL/6JGptHomozygousInnate immunity, inflammatory response

T005534

Ifnar1Cas9-KOC57BL/6JGptHomozygousViral infection, inflammatory response, oncology-immunity

T006659

Mettl3Cas9-cKOC57BL/6JGptHeterozygousM6A modification, cancers, etc.

T029037

Zbp1Cas9-KOC57BL/6JGptHeterozygousInflammatory response, necroptosis

T002625

Nfe2l2Cas9-KOC57BL/6JGptHeterozygousOxidative stress, inflammatory reaction, reproduction, etc.
T005545Tnf
Cas9-KOC57BL/6JGptHeterozygousDevelopmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,Muscle ,respiratory system,adipose tissue,Cell Proliferation,Cell death,DNA transcription,reproductive system,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,cellular,craniofacial ,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,Cell localization,Lipid Metabolism,Cytoplasmic vesicle,endosome,Organelles membrane,DNA binding protein,Physiological system,Metabolic research,Cell biology,Molecular biology
T007997Nf1
Cas9-CKOC57BL/6JGptHomozygous
Metabolic research,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell
T011566Shank3Cas9-KOC57BL/6JGptHomozygousSynapses, autism
T017245Acss2Cas9-KOC57BL/6JGptHeterozygousGlucose metabolism,liver/biliary system,homeostasis/metabolism,Lipid Metabolism,cell nucleus,ligase,Metabolic research,digestive/alimentary system,Cell biology,Molecular biology,Physiological system
T018441AclyCas9-CKOC57BL/6JGptHeterozygousGlucose metabolism,Mitochondrial research,mortality/aging,Lipid Metabolism,cell nucleus,Organelles membrane,transferase,Metabolic research,Cell biology,Developmental Biology,Molecular biology
T052147Yap1Cas9-CKOC57BL/6JGptHeterozygousHippo signaling pathway, development, growth, repair and endogenous homeostasis, cancer, etc.
T007891Mfn2Cas9-CKOC57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous
T011513Padi4-KOCas9-KOC57BL/6JGptHeterozygousImmune system,Protein metabolism,cellular,growth/size/body,hematopoietic system,mortality/aging,cell nucleus,hydrolytic
T016449Acss2Cas9-CKOC57BL/6JGptHeterozygousMetabolic research,Glucose metabolism,homeostasis/metabolism,Lipid Metabolism,Physiological system,digestive/alimentary system,liver/biliary system,Cell biology,cell nucleus,Molecular biology,ligase
T019786Sik2Cas9-CKOC57BL/6JGptHeterozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,immune system,nervous system,behavior/neurological,Physiological system,integument,pigmentation,cardiovascular system,Muscle ,Cell biology,cellular,cell nucleus,Molecular biology,Signal Transduction,transferase
T051714Tlr4Cas9-KOC57BL/6JGptHeterozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,pigmentation,cardiovascular system,skeleton,Muscle ,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Cytoplasmic vesicle,endosome,Golgi apparatus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,hydrolytic enzyme,Lipid binding protein
T008889Fabp4Cas9-CKOC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T013731Abcb11
Cas9-KOC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T052437Il33Cas9-KOC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T003346Trem2Cas9-KOC57BL/6JGptHeterozygousMetabolic research,Protein metabolism,Glucose metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,immune system,nervous system,Physiological system,cardiovascular system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Organelles membrane,Molecular biology,Signal Transduction,Lipid binding protein,Disease and Drug Evaluation Model,Neurodegenerative diseases,Huntington's disease
T016185Mthfd2Cas9-CKOC57BL/6JGptHeterozygousDevelopmental Biology,embryo,growth/size/body,mortality/aging,nervous system,vision/eye,Physiological system,integument,cardiovascular system,skeleton,craniofacial ,digestive/alimentary system,liver/biliary system,Cell biology,Mitochondrial research,Molecular biology,hydrolytic enzyme,oxidordeuctase
T052860FapCas9-KOC57BL/6JGptHeterozygousMetabolic research,Protein metabolism,Developmental Biology,immune system,nervous system,vision/eye,Physiological system,skeleton,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Organelles membrane,Molecular biology,hydrolytic enzyme


Cre Mice

Strain ID

Targeted Gene

Strain Type

Background

Genotype

Application

T004711

Adipoq-P2A-iCreCas9-KIC57BL/6JGptHomozygousTheoretically labeled cell type: White adipose tissue, brown adipose tissue

T004714

H11-Vil1-iCre-ployACas9-KI(H11)C57BL/6JGptHomozygousTheoretically labeled cell type: Gut epithelial cells

T050182

Rosa26-SA-CreERT2Cas9-KI(Rosa26)C57BL/6JGptHomozygousExpression system/tissue: Whole body (low activity in brain and skeletal muscle)

T004818

Cd4-iCreCas9-KI(H11)C57BL/6JGptHomozygousTheoretically labeled cell type: Helper T cells (CD4+ T cells)
T010829Tg(Prox1-CreERT2)TGC57BL/6JGptHeterozygousTool Mice,Cre/Dre,immune system
T036859Ckmm-iCre-PolyATGC57BL/6JGptHeterozygousCre/Dre,Tool Mice,adipose tissue,Metabolic research
T052789Lyz2-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre,immune system

T009409

H11-Stra8-iCreCas9-KI(H11)C57BL/6JGptHomozygousTheoretically labeled cell type: Seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells

T004985

Lyve1-IRES-iCreCas9-KIC57BL/6JGptHeterozygousExpressed system/tissue: immune system; Theoretically labeled cell type: lymphatic vessel endothelial cells; no cellular level validation performed.

T004712

H11-Cdh5-iCreCas9-KIC57BL/6JGptHomozygousTheoretically labeled cell type: vascular endothelial cells

T006202

Calb1-P2A-iCreCas9-KIC57BL/6JGptHeterozygousExpressed system/tissue: nervous system (see strain information for details). Theoretically labeled cell type: central neuron; no cellular level validation performed.

T006768

Cx3cr1-iCreCas9-KIC57BL/6JGptHomozygousExpressed system/tissue: immune system (see strain information for details). Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; no cellular level validation performed.

T050183

Rosa26-EIIA-iCreCas9-KI(Rosa26)C57BL/6JGptHeterozygousExpressed system/tissue: systemic (see strain information for details). Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); no cellular level validation performed.
T004829H11-Vil1-CreERT2-ployACas9-KI(H11)C57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,digestive/alimentary system
T017784alb-creERT2Cas9-KI(H11)C57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,digestive/alimentary system,liver/biliary system
T005635H11-MMTV-iCreCas9-KI(H11)C57BL/6JGptHeterozygousTool Mice,Cre/Dre
T006205Lrat-P2A-iCreCas9-KIC57BL/6JGptHomozygousTheoretically labeled cell type: Hepatic stellate cells
T052797Fos-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre,nervous system
T007046Cdh16-CreERT2Cas9-KIC57BL/6JGptHomozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T014691Cdh5-CreERT2TGC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,cardiovascular system
T055135Cd4-IRES-iCreCas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre,immune system
T050812Upk2-P2A-iCreCas9-KIC57BL/6JGptheterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T052686Cdh5-P2A-CreERT2Cas9-KIC57BL/6JGptheterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T057690Pi16-creERT2Cas9-KIC57BL/6JGptheterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T052693Aldh1l1-CreERT2Cas9-KIC57BL/6JGptHomozygousTool Mice,Cre/Dre,nervous system


Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.