Live Knockout Mice & Conditional Knockout Mice

GemPharmatech's ambitious Knockout All Project (KOAP) aims to generate KO and cKO mouse strains for all ~23,000 protein coding genes in the mouse genome. Our KO and cKO models can be used in a variety of research fields, including oncology, autoimmunity, metabolism, and neurodegeneration. Using CRISPR-Cas9 technology, we have created over 200 Cre mouse strains that were carefully designed for efficient and reliable Cre-driven recombination. These Cre mouse strains supplement our extensive cKO mouse library, allowing for nearly unlimited genetic combinations to fit your research objectives.

We offer live mice for featured strains to save time for breeding and resuscitation, which can greatly facilitate research needs. The live mice can be shipped in as soon as 2 weeks. The in-stock list below is kept up-to-date and is first come, first served.

Benefits:

  • Live mice in stock and ready to ship in as soon as two weeks

  • Largest collection of CRISPR mouse strains with over 22,000+ available knockout and conditional knockout mouse model strains with more in development. Free email alerts for the live mice of interests.

  • Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more.

In-stock List (valid through Dec 10th, 2023)

KO & cKO Mice

Strain ID

Targeted Gene

Strain Type

Background

Genotype

Application

T012747

Sting1Cas9-KOC57BL/6JGptHomozygousViral infections, innate Immunity, autoimmunity, cellular stress and autophagy

T010873

Nlrp3Cas9-KOC57BL/6JGptHomozygousInnate immunity, inflammatory response

T005534

Ifnar1Cas9-KOC57BL/6JGptHomozygousViral infection, inflammatory response, oncology-immunity
T011566Shank3Cas9-KOC57BL/6JGptHomozygousSynapses, autism
T003346Trem2Cas9-KOC57BL/6JGptHeterozygousMetabolic research, protein metabolism, glucose metabolism,homeostasis/metabolism, developmental biology, cell differentiation, immune system, nervous system, physiological system, cardiovascular system, hematopoietic system, cell biology, cell proliferation, cell death, cellular,cell localization, organelles membrane, molecular biology, signal transduction, lipid binding protein, disease and drug evaluation model, neurodegenerative diseases, huntington's disease
T010437GsdmdCas9-KOC57BL/6JGptHomozygousDevelopmental biology, mortality/aging, immune system, physiological system, digestive/alimentary system,hematopoietic system, cell biology, cell death, cellular, cell localization, cell nucleus, organelles membrane, molecular biology, signal transduction, lipid binding protein
T059534ApcCas9-CKOC57BL/6JGptHeterozygousMetabolic research, protein metabolism, homeostasis/metabolism, developmental biology, cell differentiation, embryo,growth/size/body, mortality/aging, immune system, nervous system, vision/eye,hearing/ear, behavior/neurological, synapse, physiological system, integument,pigmentation, cardiovascular system, skeleton,craniofacial, reproductive system, digestive/alimentary system, liver/biliary system, renal/urinary system, endocrine/exocrine glands, hematopoietic system, limbs/digits/tail, cell biology, cell proliferation, cell death, cytoskeleton, cellular, cell nucleus, cytomembrane, organelles membrane, molecular biology, signal transduction, DNA transcription, regulation of enzyme activity
T009945Cpt1aCas9-CKOC57BL/6JGptHeterozygousMetabolic research, developmental biology, cardiovascular system, nervous system, signal transduction, vision/eye, reproductive system, mitochondrial research, physiological system, homeostasis/metabolism, cell biology, molecular biology, cellular, mortality/aging, cell localization, lipid metabolism, cytomembrane, transferase
T050827Gpx4
Cas9-CKOC57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous system,behavior/neurological,Physiological system,cardiovascular system,reproductive system,digestive/alimentary system,liver/biliary system,Cell biology,Cell death,Mitochondrial research,cellular,cell nucleus,Organelles membrane,Molecular biology,oxidordeuctase
T012963Spp1Cas9-CKOC57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,cardiovascular system,skeleton,Muscle ,respiratory system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell death,cellular,Cell localization,Golgi apparatus,Molecular biology,Signal Transduction,DNA transcription
T029037Zbp1Cas9-KOC57BL/6JGptHeterozygousimmune system,Cell biology,cellular,cell nucleus,Molecular biology,Signal Transduction,DNA binding protein
T006112Ccr2Cas9-KOC57BL/6JGptHeterozygousMetabolic research,Developmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,vision/eye,respiratory system,Cell Proliferation,digestive/alimentary system,Protein metabolism,liver/biliary system,renal/urinary system,Physiological system,homeostasis/metabolism,behavior/neurological,cell differentiation,Cell biology,Molecular biology,cellular,growth/size/body,hematopoietic system,mortality/aging,pigmentation,Cell localization,Organelles membrane
T015901Scarb1Cas9-CKOC57BL/6JGptHeterozygousMetabolic research,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,embryo,mortality/aging,immune system,nervous system,behavior/neurological,Physiological system,cardiovascular system,Muscle ,reproductive system,digestive/alimentary system,liver/biliary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell Proliferation,cellular,Cell localization,Organelles membrane,Molecular biology,Lipid binding protein
T025397Plin2Cas9-CKOC57BL/6JGptHeterozygousMetabolic research,adipose tissue,homeostasis/metabolism,Developmental Biology,growth/size/body,immune system,nervous system,vision/eye,behavior/neurological,Physiological system,integument,reproductive system,digestive/alimentary system,liver/biliary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell localization,cell nucleus,Organelles membrane
T006659mettl3Cas9-CKOC57BL/6JGptHomozygousMetabolic research,Protein metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,Cell biology,cell nucleus,Molecular biology,Signal Transduction,RNA binding protein,transferase
T008395Apoe-floxCas9-CKOC57BL/6JGptHeterozygousMetabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,nervous system,vision/eye,hearing/ear,taste/olfaction,behavior/neurological,synapse,Physiological system,integument,cardiovascular system,skeleton,Muscle ,respiratory system,digestive/alimentary system,liver/biliary system,renal/urinary system,endocrine/exocrine glands,hematopoietic system,Cell biology,Cell Proliferation,Cell death,Cytoskeleton,cellular,Cell localization,Cytoplasmic vesicle,endoplasmic reticulum,endosome,Golgi apparatus,cell nucleus,cytomembrane,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,Regulation of enzyme activity,Lipid binding protein,transporter
T006658Sirt3
Cas9-CKOC57BL/6JGptheterozygousMetabolic research,Developmental Biology,immune system,cardiovascular system,nervous system,Signal Transduction,skeleton,adipose tissue,DNA transcription,digestive/alimentary system,Protein metabolism,liver/biliary system,Mitochondrial research,Physiological system,homeostasis/metabolism,behavior/neurological,Cell biology,Molecular biology,cellular,growth/size/body,Cell localization,Lipid Metabolism,cell nucleus,cytomembrane,DNA binding protein,hydrolytic enzyme,transferase
T051946
Stat1Cas9-CKOC57BL/6JGptheterozygousMetabolic research,Developmental Biology,immune system,integument,cardiovascular system,Tumor research,nervous system,Signal Transduction,skeleton,vision/eye,Muscle ,Cell Proliferation,Cell death,DNA transcription,digestive/alimentary system,Protein metabolism,liver/biliary system,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,Cell biology,Molecular biology,cellular,growth/size/body,hematopoietic system,limbs/digits/tail,mortality/aging,cell nucleus,DNA binding protein
T052088Cysltr2Cas9-CKOC57BL/6JGptheterozygousMetabolic research,Protein metabolism,homeostasis/metabolism,Developmental Biology,immune system,Physiological system,integument,cardiovascular system,respiratory system,Cell biology,Cell death,Organelles membrane,Molecular biology,Signal Transduction
T064127Lrp1 Cas9-CKOC57BL/6JGptheterozygousadipose tissue,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,cell differentiation,embryo,growth/size/body,mortality/aging,immune system,nervous system,behavior/neurological,synapse,integument,cardiovascular system,skeleton,Muscle ,reproductive system,liver/biliary system,limbs/digits/tail,Cell Proliferation,Cell death,Cytoskeleton,cellular,Cell localization,Cytoplasmic vesicle,endosome,Golgi apparatus,cell nucleus,cytomembrane,Signal Transduction
T011518Pf4Cas9-KOC57BL/6JGptheterozygousMetabolic research,homeostasis/metabolism,Developmental Biology,cell differentiation,Physiological system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cytoplasmic vesicle,Molecular biology,Signal Transduction,DNA transcription
T008966Dnmt1Cas9-CKOC57BL/6JGptheterozygousMetabolic research,Developmental Biology,immune system,Tumor research,nervous system,Signal Transduction,Cell Proliferation,Cell death,DNA transcription,reproductive system,Protein metabolism,Physiological system,cell differentiation,Cell biology,Molecular biology,cellular,embryo,growth/size/body,hematopoietic system,mortality/aging,cell nucleus,DNA binding protein,RNA binding protein,transferase
T013709Atp7bCas9-KOC57BL/6JGptHeterozygousMetabolic research,Protein metabolism,homeostasis/metabolism,Developmental Biology,growth/size/body,mortality/aging,immune system,nervous system,behavior/neurological,Physiological system,integument,pigmentation,Muscle ,reproductive system,digestive/alimentary system,liver/biliary system,endocrine/exocrine glands,hematopoietic system,Cell biology,cellular,Cell localization,Cytoplasmic vesicle,endoplasmic reticulum,endosome,Golgi apparatus,cytomembrane,Molecular biology,transporter,Hepatolenticular Degeneration (Wilson Disease)


Cre Mice

Strain ID

Targeted Gene

Strain Type

Background

Genotype

Application

T004714

H11-Vil1-iCre-ployACas9-KI(H11)C57BL/6JGptHomozygousTheoretically labeled cell type: gut epithelial cells

T050182

Rosa26-SA-CreERT2Cas9-KI(Rosa26)C57BL/6JGptHomozygousExpression system/tissue: whole body (low activity in brain and skeletal muscle)

T004818

Cd4-iCreCas9-KI(H11)C57BL/6JGptHomozygousTheoretically labeled cell type: Helper T cells (CD4+ T cells)
T010829Tg(Prox1-CreERT2)TGC57BL/6JGptHeterozygousTool mice, Cre/Dre, immune system
T036859Ckmm-iCre-PolyATGC57BL/6JGptHeterozygousCre/Dre, tool mice, adipose tissue, metabolic research
T052789Lyz2-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice, Cre/Dre,immune system

T009409

H11-Stra8-iCreCas9-KI(H11)C57BL/6JGptHomozygousTheoretically labeled cell type: seminiferous epithelium, testicular mesenchymal cells, spermatocytes, oogenic cells

T004985

Lyve1-IRES-iCreCas9-KIC57BL/6JGptHeterozygous

Expressed system/tissue: immune system;

Theoretically labeled cell type: lymphatic vessel endothelial cells; 

No cellular level validation performed.

T006768

Cx3cr1-iCreCas9-KIC57BL/6JGptHomozygous

Expressed system/tissue: immune system (see strain information for details);

Theoretically labeled cell types: monocytes, macrophages, microglia, NK cells, CD8+ T cells; 

No cellular level validation performed.

T050183

Rosa26-EIIA-iCreCas9-KI(Rosa26)C57BL/6JGptHeterozygous

Expressed system/tissue: systemic (see strain information for details);

Theoretically labeled cell type: systemic (expressed early in the embryo, thus achieving systemic expression); 

No cellular level validation performed.

T004829H11-Vil1-CreERT2-ployACas9-KI(H11)C57BL/6JGptHeterozygousTool mice, Cre/Dre, physiological system, digestive/alimentary system
T006205Lrat-P2A-iCreCas9-KIC57BL/6JGptHomozygousTheoretically labeled cell type: hepatic stellate cells
T052686Cdh5-P2A-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T006806Myf5-P2A-iCreCas9-KIC57BL/6JGptHeterozygousTool mice, Cre/Dre
T006589S100a4-CreERT2-PolyATGC57BL/6JGptHeterozygousTool mice
T050180Nes-P2A-iCreCas9-KIC57BL/6JGptHeterozygousTool mice, Cre/Dre
T005636H11-S100a8 (MRP8)-iCreCas9-KI(H11)C57BL/6JGptHeterozygousTool mice, Cre/Dre, immune system
T006950H11-Ctsk-iCreCas9-KIC57BL/6JGptHomozygousMetabolic research, adipose tissue, tool mice, Cre/Dre, physiological system, skeleton, muscle 
T050766Tmem119-P2A-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool mice, Cre/Dre, nervous system
T004819H11-Itgax-iCreCas9-KI(H11)C57BL/6JGptHeterozygousCre/Dre,Tool Mice,immune system
T004857H11-Gfap-iCreCas9-KI(H11)C57BL/6JGptHomozygousCre/Dre,Tool Mice,nervous system
T004858H11-Myh6-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,cardiovascular system
T006862Tagln-iCreCas9-KIC57BL/6JGptHomozygousCre/Dre,Tool Mice,cardiovascular system,Physiological system
T049832Spp1-CreERT2-IRES-EGFPCas9-KIC57BL/6JGptHeterozygousTool Mice
T052699H11-Syn1-iCreCas9-KIC57BL/6JGptHomozygousCre/Dre,Tool Mice,nervous system
T058417H11-CAG-LSL-tdTomatoCas9-KI(H11)C57BL/6JGptHomozygousTool Mice,Fluorescent protein-labeled mouse,Systemic expression of instrumental proteins,Reporter Mice
T004833H11-hKRT14-iCreCas9-KI(H11)C57BL/6JGptHeterozygousCre/Dre,Tool Mice,integument,Physiological system
T004861Pvalb-IRES-iCreCas9-KIC57BL/6JGptHeterozygousCre/Dre,Tool Mice,nervous system
T005328Pf4-P2A-iCreCas9-KIC57BL/6JGptHeterozygousCre/Dre,Tool Mice,immune system
T007005Cd8a-iCreBAC-TGC57BL/6JGptHeterozygousTool Mice,Cre/Dre,immune system
T055339Tagln-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre
T005680H11-Nphs1-iCreCas9-KI(H11)C57BL/6JGptHeterozygousTool Mice,Cre/Dre
T010853Tg(Foxp3-iCre)TGC57BL/6JGptHeterozygousTool Mice,Cre/Dre
T054722H11-Camk2a-iCre-polyACas9-KI(H11)C57BL/6JGpt
HeterozygousTool Mice,Cre/Dre
T055044Pecam1-iCre-P2A-EGFPCas9-KIC57BL/6JGptHomozygousCre/Dre,Tool Mice,Fluorescent protein-labeled mouse,Reporter Mice
T006208Ptf1a-P2A-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre
T004822Ins1-iCreCas9-kIC57BL/6JGptHeterozygousTool Mice,Cre/Dre
T004859
H11-Pax8-CreERT2Cas9-KI(H11)C57BL/6JGptHeterozygousTool Mice,Cre/Dre
T050812Upk2-P2A-iCreCas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre,Physiological system,renal/urinary system
T055140Acan-P2A-CreERT2Cas9-KIC57BL/6JGptHeterozygousTool Mice,Cre/Dre

Note: The application information of the Cre strains presented above has not been experimentally validated at cellular level.